Endocrine Abstracts

PCOS is the most common endocrine disorder affecting the women of reproductive age group and weight loss is the mainstay of management of PCOS. We performed an open-label randomised controlled trial to compare the effects of a conventional energy deficit approach (-600 kcal/day of the total energy requirements) vs. a very low-calorie diet (VLCD: 800 kcal/day) on free androgen index (FAI), body weight, and metabolic markers in women with PCOS. Forty-one eligible patients were r...

Background: An adrenal incidentaloma is defined as an adrenal mass larger than 1 cm, detected on imaging performed for an indication other than evaluation of adrenal disease. Following the European Society of Endocrinology clinical practice guideline, assessment of malignancy by imaging and hormone excess should be done simultaneously(1). To investigate whether an adrenal mass is functionally active, a thorough clinical examination is required, extended with a 1mg o...

CaSR-autoantibodies may cause auto-immune hypercalcemia through either simple blocking or biased properties. The phenotype of this rare disease is most often acquired hypocalciuric hypercalcemia (AAH) (Minanbres JCEM 2020, Makita JCI insight 2022), but sometimes hyperparathyroidism (Pelletier-Morel Intern Med 2008), in elderly. Gender, auto-immune context is variable. Blood calcium may fluctuate, and acute exacerbations may be successfully treated with predni...

Introduction: Pituitary surgery is the first line treatment for most patients with Cushing’s disease (CD) but after failure or recurrence after surgery 3 main strategies can be proposed: medical treatment (MT), a 2 nd pituitary surgery, bilateral adrenalectomy (BA). Pituitary radiotherapy is a 4th strategy, generally combined with one of the 3 others. Medical treatment (MT) emerges as an attractive strategy but there are little data on long-term control after f...

Objectives: Congenital adrenal hyperplasia (CAH) is a rare condition caused by enzyme deficiency in cortisol biosynthesis. Patients with CAH require lifelong therapy, with the aim of replacing deficient hormones (cortisol +/− aldosterone) and reducing excess androgen production. Guidelines state that the lowest effective glucocorticoid (GC dose) should be used; however, current GC therapy is suboptimal, and supraphysiological GC doses are used to reduce excess androgens....

Adipsic hypernatremia, a rare hypothalamic disorder characterized by a loss of thirst in response to hypernatremia is more often reported in children. An autoimmune mechanism has been recently demonstrated. We report two cases.Case1: A lean 67-year-old female, with a history of multilocular sclerosis, was admitted, for severe hypernatremia (162 mmol/l) with low ADH level (0.5 pmol/l; N: 0.5-2). She did not complain of thirst, despite ideomotor slowing an...

Background: Women with polycystic ovary syndrome (PCOS) have lower health related quality of life (HRQL) and more symptoms of anxiety and depression than women without PCOS, where a higher BMI is positively correlated to both lower HRQL and more symptoms of anxiety and depression. Studies on women with PCOS and severe obesity regarding symptoms of anxiety and depression are lacking.Aims: To examine if women with severe obesity and PCOS have lower HRQL an...

Sex hormone binding globulin (SHBG) is a glycoprotein which binds hormones such as testosterone. Around 97% of circulating testosterone is bound to SHBG and is therefore biologically unavailable; approximately 2–3% of testosterone is free or loosely bound to proteins such as albumin, and is biologically active, or bioavailable. Free testosterone is very technically challenging to quantify; in order to circumvent this problem, equations are used...

Pituitary irradiation is a known risk factor for the development of subsequent hormonal dysfunction. However, it has been noted that some patients do not appear to be affected after many years of follow up. The aim of this retrospective study was to identify protective factors from developing radiation induced hypopituitarism (RIH).Methods: This is a single center study of patients attending the late effects of ch...

We present two patients with an unusual cause of primary hyperparathyroidism.A 50 year old man was referred due to incidentally noted raised serum calcium consistent with primary hyperparathyroidism (adjusted calcium 3.52 mmol/L, phosphate 0.66 mmol/L, PTH (parathyroid hormone) 99.5 pmol/L, Vitamin D 46 nmol/L). An initial neck ultrasound demonstrated a 1.2x1.7 cm left sided presumed parathyroid nodule but also a cystic 3.3x3.2x1.7...